Behind every spray there is science.
FREEZE VITAMINS are based on a comprehensive scientific absorption philosophy: CryoSpray™ technology, phospholipids as bioavailability carriers, and postbiotics to support the microbiome. Below you will find the complete bibliography behind each of our choices.
The patent that changes absorption
Spray drying utilises the oral mucosa, a well-known administration route that bypasses part of digestion and first-pass metabolism. Menthol functions as a permeation enhancer, disrupting the lipid bilayer of the membrane and increasing the passive diffusion of the active ingredients.
At the same time, phospholipids act as bioavailabilty carriers, particularly for fat-soluble or poorly absorbable substances. The TRPM8 receptor, activated by menthol, explains the cooling sensation—it provides the sensory signature that transforms use into a daily ritual.
28 ingredients. Each one has a reason for being there.
Filter by target category to view our ingredients and the scientific evidence supporting them.
Ginkgo Biloba
Flavonoids and ginkgolides that enhance microcirculation and have antioxidant action. Being studied for cognitive function in the elderly.
Bacopa monnieri
It increases the activity of antioxidant enzymes and enhances serotonin and acetylcholine signalling. Studies on memory and learning.
Lion's Mane
It stimulates the production of Nerve Growth Factor (NGF), promoting neuroplasticity. Support for the nervous system.
L-Theanine
Increases alpha brain waves and regulates GABA, dopamine, serotonin. Relaxation without sedation.
Melatonin
Regulates the circadian rhythm via MT1/MT2 receptors. EFSA-approved health claim for reducing the time it takes to fall asleep.
Chamomile Extract
Binding to GABA receptors. Studied in generalized anxiety disorder and for improving sleep quality.
L-Citrulline
Converts to L-arginine and increases nitric oxide for vasodilation. Supports blood flow and athletic performance.
Panax ginseng
It affects the HPA axis and neurotransmitters. It supports energy and cognitive performance.
Maca
An adaptogenic plant from the Andes. It has an effect on the hypothalamus-pituitary axis. Studies on libido and hormonal balance.
Beetroot Extract
Nitrates that convert to nitric oxide for vasodilation. Supports endurance and normal blood pressure.
CoQ10
It participates in mitochondrial energy production. The Q-SYMBIO study showed a benefit in patients with chronic heart failure.
Pomegranate Extract
Polyphenols with strong antioxidant and anti-inflammatory action. Cardiovascular support.
Hydroxytyrosol
EFSA health claim: contributes to the protection of blood lipids from oxidative stress (5mg daily).
Hawthorn Extract
It is studied for cardiac contractility and blood flow. Traditional use and clinical studies.
Vitamin C (Ester-C)
Contributes to normal immune function and collagen synthesis. Buffered form, milder on the stomach.
Vitamin D3
It regulates gene expression via the VDR receptor. It is involved in immunomodulation and neurological function.
Zinc Bisglycinate
Important for the immune system, skin, and healing. Bisglycinate form with higher absorption than zinc oxide.
Selenium
Antioxidant element with a role in the immune system and the thyroid. Dose-dependent action.
Collagen Peptides
Meta-analysis 26 RCTs (Pu, 2023): Improvements in skin hydration and elasticity. Musculoskeletal support.
Hyaluronic Acid
Kawada Clinical Trial (2014): improved hydration after 2–8 weeks. Studies also on joints and mobility.
Astaxanthin
Powerful antioxidant with action on skin, eyes and inflammation. From the microalgae Haematococcus pluvialis.
Lutein and Zeaxanthin
AREDS2 study (JAMA, 2013): Macular support and protection from age-related macular degeneration.
Bilberry / Anthocyanins
They are being studied for microcirculation and vision support. Anthocyanins with antioxidant action.
Vitamin D3 + K2 (MK-7)
D3 supports calcium absorption, K2 MK-7 directs it to bones. Knapen: benefit to bone health.
Glucosamine
Cochrane Review (Towheed): study for the relief of osteoarthritis symptoms. Often in combination with chondroitin.
Chondroitin Sulfate
Hochberg (Ann Rheum Dis): improvement of osteoarthritis symptoms. Synergistic effect with glucosamine.
MSM
Kim YH (2006): Improvement of joint pain and function. Studies also on inflammation and muscle recovery.
Berberine
Yin (2008) and Li meta-analysis: studies on glucose and lipid metabolism in individuals with type 2 diabetes.
Curcumin
Hewlings and Kalman (2017): antioxidant and anti-inflammatory action. Schiborr (2014): formulation is critical for bioavailability.
Green Tea / EGCG
Hursel (2009) meta-analysis: effects on weight management. Catechins with antioxidant and cardioprotective effects.
Garcinia, Gymnema, Chromium
Onakpoya (Garcinia) and Cefalu (chromium): studies on appetite and glycaemic control. Results vary by study.
Magnesium Bisglycinate
Gröber (2015): supports the nervous system, muscle function and energy. Citrate form with better bioavailability than oxide.
Iron Bisglycinate
Skolmowska (2022): effective dietary interventions for iron deficiency anaemia in women. Form with higher tolerance than sulphate.
Iodine
Zimmermann (Endocr Rev): essential for thyroid function and for normal metabolism.
Citrates Complex
Shirreffs (Nutrition Reviews): hydration and electrolyte balance support. Whelton: role of potassium in blood pressure regulation.
Calcium D-Glucarate
Walaszek (Cancer Lett): support for hepatic detoxification via the glucuronidation pathway.
Vitamin B12 (Methylcobalamin)
O'Leary and Samman (Nutrients, 2010): neuroprotection and anaemia management. Methyl form without the need for hepatic conversion.
Folate (5-MTHF)
Allen (Food Nutr Bull): Bioactive form for haematopoiesis and DNA synthesis. Does not require hepatic conversion.
Postbiotics Lysate
Salminen (2021) ISAPP consensus: definition and scope of postbiotics. Aguilar-Toalá (2018): emerging category of functional ingredients.
D-Mannose and Cranberry
Kranjčec (2014): Study of D-mannose for recurrent urinary tract infections. Cochrane Review for cranberry.
All reports
Scientific sources behind each ingredient and technology. Links open in a new tab on PubMed.
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