{"id":5008,"date":"2026-05-25T10:35:35","date_gmt":"2026-05-25T10:35:35","guid":{"rendered":"https:\/\/freezevitamins.com\/?p=5008"},"modified":"2026-05-28T13:00:09","modified_gmt":"2026-05-28T13:00:09","slug":"fast-acting-oral-sprays","status":"publish","type":"post","link":"https:\/\/freezevitamins.com\/en\/fast-acting-oral-sprays\/","title":{"rendered":"Fast-Acting Oral Sprays"},"content":{"rendered":"<h4 class=\"wp-block-wd-title title wd-5aad68fc\">Why are they effective?;<\/h4>\n\n\n\n<p class=\"wp-block-wd-paragraph wd-80b65860\">The term <strong>Oral spray delivery<\/strong>\u00a0(oral sprays) and the\u00a0<strong>Bioavailability<\/strong>\u00a0Theirs are the subject of study in Pharmacokinetics and Drug Delivery Systems.<\/p>\n\n\n\n<p class=\"wp-block-wd-paragraph wd-520c783c\">Oral sprays are administered:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>sublingual<\/strong>\u00a0under the tongue<\/li>\n\n\n\n<li><strong>Cheekbones<\/strong>\u00a0(inside of the cheek)<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-wd-paragraph wd-435c335b\">The ingredients are transferred directly from the oral mucosa and transported into the bloodstream.<\/p>\n\n\n\n<p class=\"wp-block-wd-paragraph wd-2f7031f9\"><strong>\u00a0Why do they have greater or faster bioavailability<\/strong>.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Hepatic bypass (first-pass effect)<\/h3>\n\n\n\n<p class=\"wp-block-wd-paragraph wd-59395843\">In the capsules:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>stomach \u2192 intestine \u2192 liver<\/li>\n\n\n\n<li>there the so-called first-pass metabolism exists<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-wd-paragraph wd-ce7d027f\"><strong>This reduces bioavailability.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-wd-paragraph wd-101815e4\">In mouth sprays:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>The ingredients are transferred directly into the bloodstream and\u00a0<strong>they are not initially destroyed in the liver<\/strong><\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Rapid absorption from the oral mucosa<\/h3>\n\n\n\n<p class=\"wp-block-wd-paragraph wd-ab287fb5\">The oral mucosa<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>He is thin<\/li>\n\n\n\n<li>It has many blood vessels<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-wd-paragraph wd-ac703011\"><strong>Allows rapid diffusion of ingredients \u2192 faster action (in minutes)<\/strong><\/p>\n\n\n\n<h3 class=\"wp-block-heading\">No dissolution required<\/h3>\n\n\n\n<p class=\"wp-block-wd-paragraph wd-a30c0c97\">The sprays:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>dissolve in the stomach<\/li>\n\n\n\n<li>absorbed in the intestine<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-wd-paragraph wd-366c613d\">The sprays:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>It is already in liquid form<\/li>\n\n\n\n<li>absorbed directly<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">What do the surveys show<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Studies in pharmacokinetics show that:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Sublingual\/oral sprays have a shorter time to peak concentration (Tmax)<\/li>\n\n\n\n<li>present a faster onset of action<\/li>\n\n\n\n<li>they can have greater bioavailability, especially for ingredients that are heavily metabolised in the liver<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Conclusion<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Oral sprays often have faster and more effective absorption because:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>bypass the digestive system<\/li>\n\n\n\n<li>they avoid hepatic metabolism<\/li>\n\n\n\n<li>are immediately absorbed by vascularised tissues<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<div class=\"wp-block-wd-divider wd-style-line wd-7add443d\"><\/div>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n\n<h4 class=\"wp-block-heading\" style=\"font-size:0.9rem\">Bibliography (APA)<\/h4>\n\n\n\n<ul class=\"wp-block-list\">\n<li style=\"font-size:0.9rem\">Bruschi, M. L. (2015). Strategies to modify the drug release from pharmaceutical systems. Woodhead Publishing.<\/li>\n\n\n\n<li style=\"font-size:14px\">Costantino, H. R., Illum, L., Brandt, G., Johnson, P. H., &amp; Quay, S. C. (2007). Intranasal delivery: Physicochemical and therapeutic aspects. *International Journal of Pharmaceutics*, *337*(1\u20132), 1\u201324.<\/li>\n\n\n\n<li style=\"font-size:14px\">Dhakar, R. C., Maurya, S. D., Saluja, V., &amp; Fromling, M. (2011). Buccal drug delivery system: A review. International Journal of Pharmaceutical Sciences and Research, 2(1), 81\u201392.<\/li>\n\n\n\n<li style=\"font-size:14px\">Shojaei, A. H. (1998). Buccal mucosa as a route for systemic drug delivery. Journal of Pharmacy &amp; Pharmaceutical Sciences, 1(1), 15\u201330.<\/li>\n\n\n\n<li style=\"font-size:14px\">Illum, L. (2000). Transport of drugs from the nasal cavity to the central nervous system. European Journal of Pharmaceutical Sciences, 11(1), 1\u201318.<\/li>\n\n\n\n<li style=\"font-size:14px\">Pather, S. I., Rathbone, M. J., &amp; Senel, S. (2008). Current status and the future of buccal drug delivery systems. Expert Opinion on Drug Delivery, 5(5), 531\u2013542.<\/li>\n<\/ul>\n\n\n\n<h4 class=\"wp-block-heading\" style=\"font-size:0.9rem\">Bibliography (Harvard)<\/h4>\n\n\n\n<ul style=\"font-size:0.9rem\" class=\"wp-block-list\">\n<li>Bruschi, M.L., 2015. Strategies to modify the drug release from pharmaceutical systems. Cambridge: Woodhead Publishing.<\/li>\n\n\n\n<li>Costantino, H.R. et al., 2007. Intranasal delivery: physicochemical and therapeutic aspects. International Journal of Pharmaceutics, 337(1\u20132), pp.1\u201324.<\/li>\n\n\n\n<li>Dhakar, R.C. et al., 2011. Buccal drug delivery system: a review. *International Journal of Pharmaceutical Sciences and Research*, 2(1), pp.81\u201392.<\/li>\n\n\n\n<li>Shojaei, A.H., 1998. Buccal mucosa as a route for systemic drug delivery. Journal of Pharmacy &amp; Pharmaceutical Sciences, 1(1), pp.15\u201330.<\/li>\n\n\n\n<li>Illum, L., 2000. Transport of drugs from the nasal cavity to the central nervous system. European Journal of Pharmaceutical Sciences, 11(1), pp.1\u201318.<\/li>\n\n\n\n<li>Pather, S.I., Rathbone, M.J. and Senel, S., 2008. Current status and the future of buccal drug delivery systems. Expert Opinion on Drug Delivery, 5(5), pp.531\u2013542.<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>","protected":false},"excerpt":{"rendered":"<p>Hepatic bypass (first-pass effect) Rapid absorption from the oral mucosa No dissolution required What do the studies show Studies in<\/p>","protected":false},"author":6,"featured_media":5992,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[1,204],"tags":[],"class_list":["post-5008","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-freeze-news","category-science"],"acf":[],"_links":{"self":[{"href":"https:\/\/freezevitamins.com\/en\/wp-json\/wp\/v2\/posts\/5008","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/freezevitamins.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/freezevitamins.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/freezevitamins.com\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/freezevitamins.com\/en\/wp-json\/wp\/v2\/comments?post=5008"}],"version-history":[{"count":2,"href":"https:\/\/freezevitamins.com\/en\/wp-json\/wp\/v2\/posts\/5008\/revisions"}],"predecessor-version":[{"id":5010,"href":"https:\/\/freezevitamins.com\/en\/wp-json\/wp\/v2\/posts\/5008\/revisions\/5010"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/freezevitamins.com\/en\/wp-json\/wp\/v2\/media\/5992"}],"wp:attachment":[{"href":"https:\/\/freezevitamins.com\/en\/wp-json\/wp\/v2\/media?parent=5008"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/freezevitamins.com\/en\/wp-json\/wp\/v2\/categories?post=5008"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/freezevitamins.com\/en\/wp-json\/wp\/v2\/tags?post=5008"}],"curies":[{"name":"Word processor","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}